I use Symantec AV (not the up to date one, but updated definitions.)
+
Spybot S+D which i only use if i think i downloaded a virus.
+
Sygate Pro Firewall which i turn off cause it annoys me.
All the new shit thats out eats resource and slows even top end pcs down.
You will only get a virus if you allow it ie. Downloading, clicking dodgy links, letting a turk, paki, asian, black, or any other nationality i dont like use / remotely access your pc.
Forget having 5 or more progs running LOL you paranoid fucks.